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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com




Tuesday, October 18, 2011


Eosinophilia: secondary, clonal and idiopathic
Tefferi et al.  British Journal of Haematology 2006; 133: 468-492

"Blood eosinophilia signifies either a cytokine-mediated reactive phenomenon (secondary) or an integral phenotype of an underlying haematological neoplasm (primary). Secondary eosinophilia is usually associated with parasitosis in Third World countries and allergic conditions in the West. Primary eosinophilia is operationally classified as being clonal or idiopathic, depending on the respective presence or absence of a molecular, cytogenetic or histological evidence for a myeloid malignancy. The current communication features a comprehensive clinical summary of both secondary and primary eosinophilic disorders with emphasis on recent developments in molecular pathogenesis and treatment..."

Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management
A.M. Checkley et al. Journal of Infection 2010: 60: 1-20

"Eosinophilia occurs commonly in individuals returning from the tropics. In a UK series of 852 asymptomatic returning travellers, 8% had eosinophilia,
and in a Canadian series of 1605 individuals returning from the tropics 10% of asymptomatic individuals had eosinophilia.
For the purpose of these recommendations, eosinophilia is defined as a peripheral blood eosinophil count of  >0.45 109/L. Helminth infection is the commonest identifiable cause of eosinophilia in the returning traveller or migrant, rates varying from 14 to 64%. However there are multiple causes, both infectious and non-infectious, of a peripheral blood eosinophilia and patients may present to a range of specialities other than infectious diseases. These recommendations are intended to guide infection specialists investigating and managing individuals returning from the tropics with eosinophilia, and do not attempt to cover non-infectious causes comprehensively..."