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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

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viernes, 7 de junio de 2013

Corticosteroides para AEPOC (REDUCE): demasiada dosis

Emergency medicine Literature of Note
Musings on publications and studies relevant to EM.
  
Friday June 7, 2013 - Posted by Ryan Radecki
"Some of the most common practices in Emergency Medicine are only weakly tested or defined – including steroids for acute respiratory illness. What is the true minimum effective dose? How many days – 3, 5, 7, or 14? Burst or taper? Much of our practice is based on habit and mimicry, along with the general evidence that, despite ourselves, we don't seem to be doing much harm.
This is the REDUCE trial, a multi-center, randomized, double-blind, non-inferiority comparison between a 5-day and a 14-day course of 40mg oral prednisone for acute COPD exacerbation. And...it found no difference in the primary outcome measure. So, then, all's well."
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Leuppi J. et al. JAMA. 2013;309(21):2223-2231. doi:10.1001/jama.2013.5023.
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