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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

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domingo, 28 de julio de 2013

Toxicidad pulmonar de Amiodarona

DRUG SAFETY
Papiris SA et al. Drug Saf 2010; 33(7): 539-558

  • Pulmonary involvement falls into two categories of different grades of clinical significance: 
  • (i) the ubiquitous 'lipoid pneumonia', the so-called 'amiodarone effect', which is usually asymptomatic; and 
  • (ii) the more appropriately named 'amiodarone toxicity', which includes several distinct clinical entities related to the differing patterns of lung inflammatory reaction, such as:
    • eosinophilic pneumonia
    • chronic organizing pneumonia
    • acute fibrinous organizing pneumonia
    • nodules or mass-like lesions
    • nonspecific interstitial pneumonia-like and idiopathic pulmonary fibrosis-like interstitial pneumonia, desquamative interstitial pneumonia, 
    • acute lung injury/acute respiratory distress syndrome (ARDS) and 
    • diffuse alveolar haemorrhage