DRUG SAFETY
Papiris SA et al. Drug Saf 2010; 33(7): 539-558
- Pulmonary involvement falls into two categories of different grades of clinical significance:
- (i) the ubiquitous 'lipoid pneumonia', the so-called 'amiodarone effect', which is usually asymptomatic; and
- (ii) the more appropriately named 'amiodarone toxicity', which includes several distinct clinical entities related to the differing patterns of lung inflammatory reaction, such as:
- eosinophilic pneumonia
- chronic organizing pneumonia
- acute fibrinous organizing pneumonia
- nodules or mass-like lesions
- nonspecific interstitial pneumonia-like and idiopathic pulmonary fibrosis-like interstitial pneumonia, desquamative interstitial pneumonia,
- acute lung injury/acute respiratory distress syndrome (ARDS) and
- diffuse alveolar haemorrhage