SoBronEM - July 11. 2014 - By Marianne Sacasa, MD
"Beta-Adrenergic antagonists are used to treat hypertension, ischemic heart disease, heart failure, arrhythmias, migraine headache, tremor, portal hypertension, aortic dissection… the list goes on to da break of dawn.- Physiology: Competitive antagonism of beta receptor → decrease cAMP → decrease calcium → decrease contractility
- Beta 1 Selective → depressed myocardial contractility, decreased automaticity in pacemaker cells, decreased conduction velocity.
- Nonselective B Blocker→ bronchoconstriction, impaired gluconeogenesis, and decreased insulin release
- Other properties: Lipophilicity and Membrane stabilizing activity (MSA)"
http://sobroem.com/2014/07/11/b-block-tox/