Emergency Physicians Monthly- by Evan Schwarz, MD on May 8, 2015
"During a large-volume sepsis resuscitation, your choice of fluids – specially which crystalloid solution – could mean the difference between life, death and dialysis...
So how does this change my practice? For the patient that is a little dehydrated that only needs 1-2 liters of fluid, not much; it probably doesn’t matter which crystalloid you use. For those patients that are already receiving NS and are going to require a large-volume resuscitation, there is likely a benefit in switching to a more balanced approach."
http://www.epmonthly.com/features/current-features/in-sepsis-fluid-choice-matters/