of action of antiplatelet agents.
MEDEST Mag 11, 2015
MEDEST Mag 11, 2015
"A recently published article entitled “Chest pain relief in patients with acute myocardial infarction” (European Heart Journal: Acute Cardiovascular Care April 22, 2015) address in a very well documentrd way the topic about drug-to-drug interaction between morfine and antiplatelets agents in STEMI patients...
As indicated in the article recent literature indicates an increased risk of mortality in STEMI patients treated with Morphine...
Given the key importance of platelet inhibition in patients treated by PPCI for STEMI and the absence of data that may support a potential clinical benefit of morphine in patients with acute myocardial infarction, more caution should be used regarding morphine administration in STEMI patients, and a restricted morphine use seems to be reasonably recommended...
Bottom Line
- The first impact to reduce chest pain has to be reserved to Nitrates or B-blockers (where all contraindications are excluded).
- After this NRS has to be evaluated and the use of Morphine is indicated only for values above 7. For lower values Paracetamol or Aspirin are the agents of choice."
http://medest118.com/2015/05/11/drug-to-drug-interaction-new-evidences-on-morphine-and-delayed-onset-of-action-of-antiplatelet-agents/