emDocs - October 17, 2014 - By Jeremy Kim / Edited by Koyfman A and Alerhand S
"Take-Home Points
- Anti-platelet agents are commonly used by patients, particularly those with history of CAD or CVA
- Aspirin is an irreversible COX-1 inhibitor with ineffective metabolites, leading to short duration of effect. Clopidogrel has active metabolites, leading to a longer duration of effect.
- Current literature is not conclusive for management/reversal of anti-platelet agents
- For patients with ICH or highly suspected to have ICH, consider administering:
- 1-2 single-donor packed platelets and ddAVP (0.3 mcg/kg)
- Consider further platelet transfusions and ddAVP doses for larger bleeds or for dual anti-platelet therapy"
http://www.emdocs.net/platelets-ddavp-management-intracranial-hemorrhage/