EM Didactic - June 29, 2015 - By Lakshay Chanana
..."In addition to the questionable benefit, now there is mounting evidence describing constipation and colonic necrosis with the use of SPS. In 2011, FDA issued a warning with the use of SPS. There is more and more literature coming up against the use of SPS. Evidence Based Medicine has come a long way over last 50 years and we need to review this practice. So, SPS is a potentially harmful therapy to treat hyperkalemia, it has a slow onset action (if at all) and doubtful efficacy. It also carries risk of life threatening gastrointestinal complications. There is no convincing evidence that SPS increases fecal potassium losses."
http://emdidactic.blogspot.com.es/2015/06/the-story-of-kayexalate.html