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martes, 23 de junio de 2015

Púrpura trombocitopénica trombótica

emDocs
emDocs - June 22, 2015 - By Brit Long / Edited by Koyfman A and Alerhand S
"Summary
  • TTP is a clinical diagnosis: suspect TTP in a sick-appearing patient with MAHA and thrombocytopenia.
  • TTP is due to deficiency/inactivity of ADAMTS13.
  • The classic pentad is rare, but you can depend on MAHA and low platelets for diagnosis.
    • A neurologic finding, low platelets with purpura, microangiopathic hemolytic anemia (MAHA), fever, and acute renal failure/injury
  • Schistocytes are present in 100% of cases at some point in the disease course.
  • Treatment is plasma exchange. FFP can assist if exchange is delayed.
  • Avoid platelet transfusion if possible."
http://www.emdocs.net/thrombotic-thrombocytopenic-purpura-pearls-and-pitfalls/