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Friday, January 22, 2016

Beta-Lactam Infusion in Severe Sepsis

The Bottom Line - Jan 21 2016 - By Adrian Wong
Abdul-Aziz. ICM 2016; doi:10.1007//s00134-015-4188-0
"Clinical Question
  • In adult ICU patients with severe sepsis does the use of continuous infusion (CI) of beta-lactam antibiotics compared to intermittent bolus (IB) improve clinical outcomes?
The Bottom Line
  • This study confirms that CI has a superior PK/PD profile compared to IB regiments
  • The higher clinical cure rate, ventilator free days and faster resolution of white cell count in the CI group did not translate to a mortality benefit at both 14 and 30 days
  • Given the weakness in this study and the simplicity of IB regiment, I will continue to use this in my daily practice"
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