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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com




Monday, January 4, 2016

DePPaRT study

Resultado de imagen de Deppart study Canadian transplant
Canadian National Transplant Research Program
"The dying process is a natural part of life, and while difficult and sad, can also present opportunities for new beginnings through organ and tissue donation. When possible, the opportunity to donate organs after death should be integrated into good end of life care. A growing number of organ donations in Canada are resulting from “donation after circulatory death” (DCD) a type of donation that can occur in situations where a person has no hope of recovery and life support therapy will be removed, but they do not meet stringent testing criteria for brain death. Physicians and the public are generally supportive of DCD, but ethical and logistical concerns continue to hinder its uptake. Some of these concerns include:
  • the inability to predict which donors will die within a time frame that enables them to proceed to donation, 
  • the lack of consensus on the definition of circulatory death and how to diagnose it, and 
  • disagreement about how long to wait, after circulation stops, before organ procurement can begin.
...In 2014, the DDePICt team received funding as part of the Canadian National Transplant Research Program to carry out the observational study: “Death Prediction and Physiology after Removal of Therapy (DePPaRT)”. The DePPaRT study, which is currently underway, will recruit 500 patients at 13 sites across Canada, and several sites internationally including in the Czech Republic and the United Kingdom. The DePPaRT study will document the physiology of the dying process and, under the leadership of Dr. Jason Shahin from McGill University, will also aim to develop a tool that will allow doctors to predict how long it will take patients to die after the removal of life sustaining therapy. A qualitative component of the study let by Prof. Jennifer Chandler from the University of Ottawa will investigate the decision-making surrounding consent for organ donation and how family members felt when their loved ones became organ donors or were unable to proceed to donation. Results from both the quantitative and qualitative aspects of this study will inform DCD policy and practice and could lead to improvements in the uptake of the practice, both nationally and internationally. The DePPaRT study aims to address the shortage of available organs in Canada by first addressing directly our shortage of empirical knowledge about donation processes."