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Monday, February 1, 2016

Intravenous olanzapine

Resultado de imagen de PulmCrit (Em crit)
PulmCrit - February 1, 2016 by Josh Farkas
  • "Intravenous use of haloperidol is not FDA-approved, but is widely utilized and accepted in the literature.
  • Recent studies suggest that olanzapine can also be given intravenously, even though it is labeled only for intramuscular use.
  • One RCT showed that IV olanzapine was as effective as IV droperidol.
  • Olanzapine does not cause torsade de pointes, nor does it require monitoring with serial EKGs.
  • The rate of extrapyramidal side effects with olanzapine is lower than with haloperidol.
  • Intravenous olanzapine may be an attractive alternative to intravenous haloperidol, particularly among patients at risk for arrhythmia."