Lipid use in poisoning

Title: Lipid use in poisoning: comprehensive systematic reviews now published

Keywords: lipid, intralipid, poisoning, local anesthetic, non-local anesthetic (PubMed Search)

Posted: 2/10/2016 by Bryan Hayes, PharmD (Emailed: 2/11/2016) (Updated: 2/11/2016)
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In September 2013, an international group representing major societies in toxicology and nutrition support began collaborating on a comprehensive review of lipid use in poisoning. Six total papers will be published, with the most recent two made available online this week. Here are the available (and forthcoming) papers:

1. Gosselin S, et al. Methodology for AACT evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol 2015;53(6):557-64. [PMID 26059735]
2. Grunbaum AM, et al. Review of the effect of intravenous lipid emulsion on laboratory analyses. Clin Toxicol2016:54(2):92-102. [PMID 26623668]
3. Levine M, et al. Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity.Clin Toxicol. 2016 Feb 6. [Epub ahead of print] [PMID 26852931]
4. Hoegberg LC, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol. 2016 Feb 6. [Epub ahead of print] [PMID 26853119]
5. Hayes BD, et al. Systematic Review of Clinical Adverse Events Reported After Acute Intravenous Lipid Emulsion Administration. Clin Toxicol. [Accepted for publication]
6. The final paper, which is in process, is the consensus recommendations from the workgroup based on the 4 systematic reviews.