Sin B, et al. Acad Emerg Med. 2016 Jan 29. doi: 10.1111/acem.12921
"OBJECTIVES:
Acetaminophen is a mainstay for pain management worldwide. The intravenous (IV) formulation has been widely used in Europe for more than 20 years in adults and children. In the United States, IV acetaminophen (APAP) obtained full approval from the Food and Drug Administration (FDA) in 2010. There is emerging literature to suggest the use of IV APAP for pain reduction in the Emergency Department (ED). This evidence-based review examines the evidence pertaining to the use of IV APAP for acute pain control in the ED.
CONCLUSION:
Fourteen randomized controlled trials with various methodological flaws provided limited evidence to support the use of IV APAP as the primary analgesic for acute pain control in patients who presents to the ED."