Patrick J. van der Geest et al. Critical Care 2016; 20:180
DOI: 10.1186/s13054-016-1366-6 - Published: 7 July 2016
"The ICIS score is composed of five blood-cell-derived parameters that characterize the innate immune response. The five parameters include the mean fluorescence intensity of mature (segmented) neutrophils, the difference in hemoglobin concentration between newly formed and mature red blood cells, the total segmented neutrophil count, the antibody secreting lymphocytes, and the accurate immature granulocytes count. Each parameter is available from a standard routine method and can be measured within 1 minute without sample preparation on a modified fluorescence flow hematology analyzer with fully automated gating (Symex)
Background
The prediction of infection and its severity remains difficult in the critically ill. A novel, simple biomarker derived from five blood-cell derived parameters that characterize the innate immune response in routine blood samples, the intensive care infection score (ICIS), could be helpful in this respect. We therefore compared the predictive value of the ICIS with that of the white blood cell count (WBC), C-reactive protein (CRP) and procalcitonin (PCT) for infection and its severity in critically ill patients.
Conclusion
The data suggest that the ICIS is potentially useful for the prediction of infection and its severity in critically ill patients, non-inferiorly to CRP and PCT. In contrast to CRP and PCT, the ICIS can be determined routinely without extra blood sampling and lower costs, yielding results within 15 minutes."