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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

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lunes, 12 de septiembre de 2016

Blast Crisis

emDocs - September 10, 2016 - Authors: Patrick C Ng and Long B -  Editors: Robertson J
"Summary
  • CML is a myeloproliferative disorder that can present at any age, but typically presents in the 6th decade of life
  • CML has three phases: Chronic(most common), Accelerated, and Blast
  • Blast phase is a poor prognostic factor
  • Blast phase can present in a variety of ways including but not limited to eye pain, vision changes, neurologic complaints, joint pain, and bleeding. The emergency provider must maintain a high suspicion for this diagnosis, particularly in patients that carry a diagnosis of CML, although these can serve as initial presentations of the disease as well
  • Blast phase can present in conjunction with other pathology including but not limited to fractures and infections. The emergency provider must be aware of this key point to properly address these pathologies in the initial resuscitation and management of the patient.
  • Tyrosine kinase inhibitors serve as the first line of treatment for CML, those progressing to later phases may require other specialized therapy such as combination therapy or cell transplantation that will require expert consultation with a hematologist/oncologist."