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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

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lunes, 17 de octubre de 2016

Hydrocortisone and Severe Sepsis

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The Bottom Line - October 14, 2016 - By Celia Bradford
Ref. Keh. JAMA 2016. Published online October 3, 2016.doi:10.1001/jama.2016.14799
"Clinical Question
In patients with severe sepsis does hydrocortisone compared to placebo prevent the development of septic shock?
Authors’ Conclusions
Administration of hydrocortisone did not prevent the development of shock in patients with severe sepsis.
The Bottom Line
As a non-believer in the use of steroids in sepsis and septic shock I will continue my current practice of not using steroids in this setting.
I am working at a hospital actively recruiting for the ADRENAL trial. 3800 patients with septic shock are being recruited in a placebo-controlled trial to assess 90 day mortality. I keenly await these results which may put this question to rest forever!"