WORLD EMERGENCY MEDICINE SOCIETIES & RELATED

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Wednesday, January 4, 2017

Ephenidine

Heather Kanga H et al. Neuropharmacology 2017; 112; 144-149
"Highlights
  • New ‘legal high’, the dissociative ephenidine, displaces MK-801 binding.
  • Ephenidine, like ketamine, blocks NMDA receptor mediated synaptic potentials and plasticity.
  • Ephenidine, like ketamine, blocks the NMDA receptor in a highly voltage-dependent manner.
  • Ephenidine blocks long-term potentiation, LTP.
  • NMDA receptor antagonism likely underlies the psychoactive effects of ephenidine."