Ephenidine

Ephenidine: A new psychoactive agent with ketamine-like NMDA 

receptor antagonist properties

Heather Kanga H et al. Neuropharmacology 2017; 112; 144-149

"Highlights

• New ‘legal high’, the dissociative ephenidine, displaces MK-801 binding.
• Ephenidine, like ketamine, blocks NMDA receptor mediated synaptic potentials and plasticity.
• Ephenidine, like ketamine, blocks the NMDA receptor in a highly voltage-dependent manner.
• Ephenidine blocks long-term potentiation, LTP.
• NMDA receptor antagonism likely underlies the psychoactive effects of ephenidine."