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Saturday, February 11, 2017

Methylene blue vs Vasopresin

The Bottom Line - February 10, 2017 By Duncan Chambler
Ref. El Adawi. Ain-Shams J Anaesthesiol 2016;9:319-24. doi:10.4103/1687-7934.189091
"Clinical Question
In adult patients with severe sepsis, does methylene blue compared to vasopressin reduce noradrenaline requirement and increase blood pressure?
Authors’ Conclusions
In sepsis-induced refractory vasoplegia methylene blue may be more effective than vasopressin but further studies are required
The Bottom Line
Although an exciting and relevant clinical question, the methodological flaws in this study potentially introduce far too many biases for the conclusion to be accepted
Further patient-centred trials are required before I will be reaching for the methylene blue"