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miércoles, 15 de febrero de 2017

O2 Sat in Critical illness

PulmCrit - February 15, 2017
Ref. Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit. The Oxygen-ICU Randomized Clinical Trial. JAMA. 2016 Oct 18;316(15):1583-1589.
"Oxygen is essential for life, but by forming superoxides and free radicals, supplemental oxygen can also inflict damage on lung and other body tissues.
The sweet spot for oxygen delivery in critically ill patients is unknown, but increasing evidence suggests that when it comes to blood oxygen saturation during critical illness, "normal" levels might actually be harmful...
...this is not a conclusive study by any stretch of the imagination. But given the mounting suggestion of possible harm from high normal or supranormal arterial oxygen levels, and the apparent absence of harm from low-normal oxygenation, it seems prudent to target oxygen saturation in the mid-90s percent for many, if not most critically ill patients."