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martes, 11 de abril de 2017

Submassive PE 2017

PulmCrit (EMCrit)
PulmCrit - April 10, 2017 - By Josh Farkas
  • "Long-term outcomes of patients in the PEITHO trial indicate that thrombolysis doesn't affect chronic pulmonary morbidity. This simplifies the approach to submassive PE, by making the primary goal of thrombolysis to avoid PEA arrest.
  • Patients with low-risk submassive PE who are less likely to arrest probably don't benefit from thrombolysis. However, high-risk submassive patients may still benefit from thrombolysis.
  • If our goal from thrombolysis is merely to avoid PEA arrest, all we need to do is reduce the pulmonary pressures somewhat (not normalize them). This may be achievable with lower doses of alteplase than have been used historically, with a superior safety profile."