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miércoles, 21 de junio de 2017

IV Lipid emulsion for drug toxicity

CanadiEM - By Jared Baylis - June 20, 2017
  • Lipid emulsion therapy has provided an exciting avenue of therapy with potential survival benefit in severe drug toxicity
  • Most of the evidence is from case reports which are subject to several biases including positive reporting bias
  • The ASRA guidelines provide the most agreed upon guidance for dosage (100mL 20% lipid emulsion bolus followed by 18mL/min infusion for 30 mins)
  • Consider lipid emulsion therapy in patients presenting with refractory cardiovascular collapse secondary to drug toxicity where the offending agent is lipophilic and there are no further viable options for treatment
  • Adverse effects are rare if your infusion rate is less than 0.55 mL/kg/min and your daily dose is less than 10mL/kg"