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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

WORLD EMERGENCY MEDICINE SOCIETIES

Cranial Nerve VI Palsy Emergency

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martes, 21 de noviembre de 2017

TXA in Massive Hemorrhage

R.E.B.E.L.EM - Nov 20, 2017
Background: Bleeding from massive hemorrhage in trauma and post-partum are a major cause of death worldwide. There have been two large randomized controlled trials, in trauma and post-partum hemorrhage that have shown administration of TXA within 3 hrs of bleeding onset reduces death due to bleeding. The current meta-analysis that we are going to review sought to quantify the effect of treatment delay in acute severe bleeding by analyzing individual patient-level data from the two randomized clinical trials mentioned above...
Clinical Take Home Point: 
  • In patients with massive bleeding from trauma or post-partum hemorrhage, giving TXA as soon as bleeding is suspected, reduces mortality from bleeding.
  • Most deaths, in trauma and postpartum from hemorrhage, occur within hours of bleeding onset
  • The mortality benefit of TXA appears to diminish over time and is lost at 3 hours after major hemorrhage begins
  • In this trial, there was no evidence of adverse effects (vascular occlusive events) associated with TXA treatment"