Venkatesh. NEJM 2018; published on line first 19th January 2018 DOI: 10.1056/NEJMoa1705835
The Bottom Line - January 20, 2018 - By David Slessor
"The Bottom Line
- In mechanically ventilated patients with septic shock, low dose hydrocortisone administered via an infusion for up to 7 days does not reduce or increase mortality at 90 days
- Secondary outcomes demonstrated that patients in the hydrocortisone group had a reduced time to resolution of shock, reduced duration of ICU but not hospital stay, reduced time to cessation of mechanical ventilation and a reduction in the use of blood transfusion. Adverse events were low, but significantly increased in the hydrocortisone group"