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Saturday, March 31, 2018

DEFUSE 3

The Bottom Line - By Anthony Hackett - March 30, 2018
Albers et Al, N Engl J Med 2018; 378:708-718 DOI: 10.1056/NEJMoa1713973
"Clinical Question
  • In patients with proximal internal carotid (ICA) or middle cerebral artery (MCA) occlusion with likely salvageable ischaemic brain tissue, does thrombectomy, at 6-16 hours post ischaemic stroke, in addition to medical therapy, compared to medical therapy alone, improve functional outcome at 90 days?...
The Bottom Line
  • In patients with large vessel strokes with favourable ischaemic core to penumbra ratios, endovascular therapy at 6-16 hours post stroke onset in addition to medical therapy, improved functional neurological outcome at 90 days, compared with medical therapy alone
  • These are promising results but given the specific selection criteria, and the need for advanced imaging and intervention it is unclear how broad the actual benefit in clinical practice will extend."