emDocs - April 30, 2018 - By Author: Webb J - Edited by: Koyfman A and Long B
"Key Points:
- Anti-GBM disease is caused by circulating auto-antibodies to the basement membrane resulting in glomerulonephritis and alveolar hemorrhage.
- Labwork frequently shows elevated BUN and creatinine; UA with hematuria, proteinuria, and RBC casts.
- CXR may show bilateral diffuse patchy alveolar infiltrates.
- Symptoms can progress quickly and often require intubation and dialysis.
- Empiric treatment with high-dose glucocorticoids (IV Methylprednisolone) can be started with high clinical suspicion."