Friday, May 25, 2018

Corticosteroids in Pharyngitis

R.E.B.E.L.EM - May 24, 2018 - By Allon Mordel
Clinical Question:
Do single, low dose corticosteroids provide symptomatic relief in undifferentiated pharyngitis without significant adverse effects?
Author’s Conclusions:
“Single low dose corticosteroids can provide pain relief in patients with sore throat, with no increase in serious adverse effects.”
Our Conclusions:
Of all the outcomes, only the complete resolution of symptoms at 48 hours is backed by high quality evidence and a narrow confidence interval. Steroids also appear to provide only a moderate improvement in time to and degree of resolution of symptoms. However, in the setting of severe symptoms, these moderate improvements could make a significant difference.
Potential to Impact Current Practice:
This study validates prior studies suggesting corticosteroids offer therapeutic benefit in the management of sore throat. Clinicians should strongly consider adding a single dose of corticosteroids to their treatment regimen for patients with pharyngitis.
Bottom Line:
In cases of severe pharyngitis, single low dose corticosteroid administration would likely provide symptomatic benefit that outweigh potential adverse effects.