PulmCCM - June 7, 2018
"Infusing antipseudomonal beta-lactam antibiotics over longer periods could save lives in sepsis over intermittent bolus dosing, according to a systematic review and meta-analysis of randomized trials.
Vardakas et al aggregated data from studies of patients with sepsis receiving infusions of carbapenems, cephalosporins, and penicillins with antipseudomonal activity. Studies included compared prolonged infusion (over at least three hours), vs. hour-long infusions or shorter. They included 22 randomized trials with 1,876 patients.
Prolonged infusion of antipseudomonal beta-lactams reduced mortality by 30% compared with shorter infusions. Findings were published in Lancet Infectious Diseases..."