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lunes, 13 de agosto de 2018

Behavioral Control

R.E.B.E.L.EM - August 13, 2018
Article: Klein LR et al. Intramuscular midazolam, olanzapine, ziprasidone, or haldoperidol for treating acute agitation in the emergency department. Ann Emerge Med 2018. PMID: 29885904
"Potential to Impact Current Practice:
If rapid sedation with a high chance for success with a single agent is desired, IM midazolam is your drug of choice. Olanzapine should be considered over haloperidol if available. This study does not add to our understanding of sedation of the severely agitated patient.
Bottom Line:
IM midazolam 5 mg achieves a high-success rate of sedation at 15 minutes with the caveat of increased need for additional medications during the ED course due to its short activity."