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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

WORLD EMERGENCY MEDICINE SOCIETIES

EMU 365: Best Emergency Medicine Articles of the Year 2018

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jueves, 10 de enero de 2019

Valproic Acid Toxicity

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emDocs - January 10, 2019 - Author: Yip K
Edited by: Tanen D, Santos C, Koyfman A and Long B
"Take home points
  • Check serial valproic acid levels to make sure it is downtrending.
  • CNS effects (e.g. somnolence, confusion) are most common.
  • Valproic acid induced hyperammonemia encephalopathy may be seen even without hepatotoxicity or elevated VPA levels.
  • Supportive care is key, though L-carnitine may be helpful."