emDocs - January 10, 2019 - Author: Yip K
Edited by: Tanen D, Santos C, Koyfman A and Long B
"Take home points
- Check serial valproic acid levels to make sure it is downtrending.
- CNS effects (e.g. somnolence, confusion) are most common.
- Valproic acid induced hyperammonemia encephalopathy may be seen even without hepatotoxicity or elevated VPA levels.
- Supportive care is key, though L-carnitine may be helpful."