R.E.B.E.L.EM - October 10, 2019 - By Rezaie S
..."Author Conclusion: “In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30cc/kg LR bolus. There was no difference in mean serum lactated when comparing a 30mL/kg bolus of NS to LR.”
Clinical Take Home Point: In healthy volunteers the use of 30cc/kg of LR or NS both slightly increase lactate levels, however the duration of this effect, effect on patient oriented outcomes, effect on patients with renal/liver impairment, and the effect on patients with acute illness cannot be generalized based on this study. I will continue to use balanced crystalloids in large volume resuscitations until further evidence indicates that this is causing harm to patients."