Síguenos en Twitter     Síguenos en Facebook     Síguenos en YouTube     Siguenos en Linkedin     Correo Grupsagessa     Gmail     Yahoo Mail     Dropbox     Instagram     Slack     Google Drive     Print     StumbleUpon     StumbleUpon     StumbleUpon     StumbleUpon

SOBRE EL AUTOR **

Mi foto
FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

WORLD EMERGENCY MEDICINE SOCIETIES & RELATED

iEM Education Project in 12 Questions (https://iem-student.org/)

Buscar en contenido

Contenido:

martes, 26 de noviembre de 2019

Controlled aquaresis

PulmCrit (EMCrit)
PulmCrit- November 26, 2019 - By Josh Farkas
View image on Twitter

"Summary The Bullet:

  • Oral urea therapy is finally available in the United States. Urea functions as an osmotic diuretic (a.k.a. aquaretic), with potential use in euvolemic or hypervolemic hyponatremia.
  • No RCTs exist comparing oral urea to alternative therapies (e.g. vaptans). However, oral urea is widely regarded as very safe (it’s classified by the FDA as a “medicinal food”). An emerging body of evidence suggests that oral urea is a safe and effective therapy for many forms of hyponatremia.
  • Although oral urea is perceived as a “new” therapy in the United States, it has been used for decades in Europe. For example, urea was recommended for management of SIADH in the 2014 European guidelines.​
  • Oral urea has important advantages compared to vaptans: it is cheaper and will not cause uncontrolled excretion of free water (thus, urea is unlikely to cause osmotic demyelination syndrome and requires less intensive monitoring than vaptans)."