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Monday, February 3, 2020

Tamiflu

Tamilfu doesn't work
First10EM - By Justin Morgenstern - February 3, 2020
"The paper: Butler CC, van der Velden AW, Bongard E, et al. Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial. Lancet. 2020; 395(10217):42-52. PMID: 31839279 ISRCTN27908921
Bottom line
The positive findings in this unblinded trial are completely unconvincing. Based on plaebo controlled studies, we know that tamiflu doesn’t change any important, objective outcomes. It may decrease the length of illness slightly, although the studies that report than benefit have a high risk of bias. However, it causes side effects that patients tend to find worse than the flu itself. Personally, I do not and will not prescribe Tamiflu."
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