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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

WORLD EMERGENCY MEDICINE SOCIETIES & RELATED

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domingo, 7 de junio de 2020

Early Norepi in Septic Shock

SGEM#294 - By Ken W - Jun 6, 2020
Reference: Permpikul et al. Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): A Randomized Trial. Respir Crit Care Med 2019.

"CLINICAL QUESTION: DOES STARTING NOREPINEPHRINE EARLIER IN SEPTIC SHOCK LEAD TO EARLIER SHOCK CONTROL?
Authors’ Conclusions: “Early norepinephrine was significantly associated with increased shock control by 6 hours. Further studies are needed before this approach is introduced in clinical resuscitation practice.” 
SGEM BOTTOM LINE: EARLY NOREPINEPHRINE CAN CHANGE SOME MOOS (MAP, LACTATE, URINARY OUTPUT) BUT DOES NOT SEEM TO CHANGE ANY POOS (IN-HOSPITAL OR 28-DAY MORTALITY) IN ADULT PATIENTS WITH SEPTIC SHOCK."