emDocs - June 18, 2020 - By Furmick J, Murphy C
Reviewed by: Santos C; Koyfman A and Long B
"Anti-NMDA receptor encephalitis is a very specific autoimmune mediated reaction against the NMDA receptor that leads to down regulation of the receptor presenting as a variety of psychiatric and neurologic symptoms. Originally described as a paraneoplastic syndrome and seen exclusively in women with ovarian teratomas, it has since been described in those without tumors...
"Key points:
- Anti-NMDA receptor encephalitis is an autoimmune reaction targeting the NMDA receptor.
- Patients present with both psychiatric and neurologic symptoms.
- 50% of cases are associated with ovarian teratomas.
- Labs and imaging can be normal.
- Treatment includes steroids + IVIG or plasmapheresis."