First 10EM - By Justin Morgenstern - June 19, 2020
"The paper
Brenner, A., Afolabi, A., Ahmad, S.M. et al. Tranexamic acid for acute gastrointestinal bleeding (the HALT-IT trial): statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. Trials 20, 467 (2019). https://doi.org/10.1186/s13063-019-3561-7 PMID: NCT01713101
Bottom line
This is a very high quality RCT that demonstrated no benefit from TXA in GI bleeding, and a small increase in venous thromboembolism. TXA should not be routinely used for GI bleeding."