First10EM -July 27, 2020 - By Justin Morgenstern
The paper: Warren J, Cooper B, Jermakoff A, Knott JC. Antacid monotherapy is more effective in relieving epigastric pain than in combination with lidocaine. A randomized double-blind clinical trial. Acad Emerg Med. 2020;10.1111/acem.14069. doi:10.1111/acem.14069 PMID: 32602148 Australian New Zealand Clinical Trials Registry ACTRN12619000928112
"Bottom line
In this single centre RCT, adding lidocaine to an antacid provided no extra pain relief, but increased adverse events and decreased the palatability of the medication. The trial is imperfect, but there is no reason to prescribe the “GI cocktail” or “pink lady” at this time."