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SOBRE EL AUTOR **

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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com

WORLD EMERGENCY MEDICINE SOCIETIES & RELATED

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lunes, 28 de septiembre de 2020

TXA in TBI

First 10EM - September 28, 2020 - By justin Morgenstern
The paper
Rowell SE, Meier EN, McKnight B, et al. Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury. JAMA. 2020 Sep 8;324(10):961-974. doi: 10.1001/jama.2020.8958. PMID: 32897344. ClinicalTrials.gov Identifier: NCT01990768

...There was no difference in the primary outcome of favourable neurologic outcome on the GOSE score. 58% of the bolus/infusion group, 62% of the bolus only group, and 60% of the placebo group had a favourable outcome...

Bottom line
This is a large, double-blind RCT that demonstrated no benefit from giving TXA in the prehospital setting for traumatic brain injury. The trial is not definitive, but I believe the results.