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FACP. Colegio de médicos de Tarragona Nº 4305520 / fgcapriles@gmail.com




Sunday, November 15, 2020

Covid-19 Update

REBEL.EM - November 13, 2020 - By Salim Rezaie
"Background: There have been lots of trials sitting on my computer desktop awaiting my review, but like many of you time has been thin from clinical work and increasing cases of COVID-19 where I work. I thought it might be more effective to give you the Cliff’s Notes highlights of each since the time for deep dives remains elusive. As always, I urge you to read each of the papers yourselves and come to your own conclusions.
Thus far in the pandemic, there have been few treatment options available to manage COVID-19. Many clinicians have been using repurposed drugs with scant data as well as other non-drug interventions. Let’s get into some recent data behind these interventions.
WHO SOLIDARITY Interim Results [1]
Clinical Question: Does the use of remdesivir reduce mortality in hospitalized patients with COVID-19? (The authors also looked at hydroxychloroquine, lopinavir, and interferon-B1a in this trial, but we are going to focus on remdesivir only)
PLACID Trial [2]
Clinical Question: Is convalescent plasma + standard care more effective than standard care alone in moderate COVID-19?
Clinical Question: In patients with severe COVID-19 does therapeutic enoxaparin or standard anticoagulant thromboprophylaxis improve gas exchange over time?
COVID-19 Related Organ Dysfunction and Management Strategies Review [4]
Optimal organ support and adjunctive therapies for COVID-19 have not yet been well established by trial-based outcomes thus far. The authors of this paper did a review of relevant pathophysiology and management strategies for critically ill patients with COVID-19 based out of the UK. Of the 100s of papers I have read on COVID-19, this is one of the best reviews I have read to date."