REBEL CRIT - March 08, 2021 - By Salim Rezaie
Article: Schjorring O et al. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. NEJM. Jan 2021. PMID 33471452 [Access on Read by QxMD]
“Clinical Question: Does lower oxygenation with PaO2 60 mmHg reduce 90-day mortality compared to higher oxygenation with PaO2 90 mmHg in patients admitted to ICU with acute hypoxemic respiratory failure?
Author’s Conclusion: “Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days.”
Clinical Take Home Point: This study adds very little new information into clinical practice and does not provide a definite answer for specific oxygenation parameters. Current evidence shows we should embrace lower PaO2 and SaO2 and continue to wean FiO2 as quickly and safely as possible while ensuring to not expose patients with suboptimal oxygen saturations. While we await the results of larger trials like MEGA-ROX, targeting an SpO2 of 92 to 96% (PaO2 60 to 90) is the ideal target.”Lotería vs Higuera O2”