EmDocs - March 13, 2021 - Andrea Nillas
Reviewed by: Kerollos Shaker, Nancy Onisko, Alex Koyfman, Brit Long
“Pearls:
- Consider with history of polypharmacy, antidepressant, or opioid use
- Presentation has fast onset and resolution
- Clonus is a key physical exam finding
- Hyperthermia, seizures, and rhabdomyolysis indicate severe serotonin syndrome
- Treatment is supportive, targeting hyperthermia and agitation”