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Friday, April 16, 2021

Thrombolytics for AIS

First10EM EM - By Justin Morgenstern and Ken Milne - April 15, 2021
...”This is the third NNT summary of thrombolytics for acute ischemic stroke. The first gave thrombolytics, as a class, a ‘red color recommendation: no benefit. The second gave alteplase, a single agent, a ‘green color recommendation: benefit>harm. As no relevant trials were published between the two, both author groups examined essentially the same data and arrived at opposing conclusions. We believe it would be hubris to presume this third summary will arrive at the one true answer. We focus, therefore, on the uncertainty we believe leads to conflicting interpretations...”