WORLD EMERGENCY MEDICINE SOCIETIES & RELATED

Search

Content:

Thursday, May 13, 2021

PRIS

CRITICALCARENOW
CRITICALCARENOW - By Lauren Igneri - May 13, 2021
“The Debrief
  • Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition caused by shifts in intracellular energy production.
  • Clinical features including fever, hyperkalemia, hypotension, ECG changes, traumatic brain injury, mean infusion rate >5 mg/kg/h, duration of infusion >48 hours, and cumulative dose >240 mg/kg are associated with increased mortality in PRIS.
  • Propofol should be dosed using ideal body weight in obese patients to minimize the risk for developing PRIS.”