CRITICALCARENOW
CRITICALCARENOW - By Lauren Igneri - May 13, 2021
- Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition caused by shifts in intracellular energy production.
- Clinical features including fever, hyperkalemia, hypotension, ECG changes, traumatic brain injury, mean infusion rate >5 mg/kg/h, duration of infusion >48 hours, and cumulative dose >240 mg/kg are associated with increased mortality in PRIS.
- Propofol should be dosed using ideal body weight in obese patients to minimize the risk for developing PRIS.”