ALiEM - Aug 21, 2021 - By: Mike O'Brien and Bryan D. Hayes
Bottom Line
- A unit of FFP has an INR of ~1.1, but this doesn’t mean it can easily normalize the INR.
- There is a non-linear relationship between percentage of clotting factors and the INR, resulting in diminishing returns from each unit of FFP as the INR decreases.
- Very large doses of FFP may be required to fully correct an elevated INR, which frequently precludes its use.
- Complete normalization of the INR is not required to achieve hemostasis or prevent bleeding from a procedure.