WORLD EMERGENCY MEDICINE SOCIETIES & RELATED

Search

Content:

Monday, September 27, 2021

Alteplase for Stroke

REBEL EM / Rebelion21 - September 25, 2021 - By Salim Rezaie
“Bottom Line: This meta-analysis provides level 1a evidence for the use of advanced brain imaging beyond non-contrast CT to help guide treatment with intravenous alteplase in patients with acute ischemic stroke with an unknown time of onset. However, despite a consistently better functional outcome at 90d with alteplase compared to placebo or standard of care there was still an increased risk of symptomatic intracranial hemorrhage and a higher mortality which has also been consistent across all randomized clinical trials.”