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Monday, October 11, 2021

Oxygenation Targets for AHRF

EMOttawa - By Hans Rosenberg - October 11, 2021
Question and Methods: Can a lower PaO2 target (i.e., 60mmHg) compared to higher PaO2 target (i.e., 90mmHg) decrease all cause 90 day mortality by more than 5% in patient with acute hypoxemic respiratory failure requiring >10L of O2?
Findings: At 90 days, all-cause mortality between the high and low PaO2 targe\RFt groups was not statistically different (42.4% and 42.9%, respectively) (RR: 1.02; 95% CI 0.94 – 1.11; P=0.64).
Limitations: Major limitations included not meeting the lower PaO2 target and no standard ABG protocol.
Interpretation: It is reasonable to target lower SpO2 (90-96%) for patients with acute hypoxemic respiratory failure requiring oxygenation