Canadi EM - February 8, 2022 - By Victoria Forcina
Takeaways:
„Both serotonin syndrome and neuroleptic malignant syndrome are key diagnoses to be considered in the differential for the hyperthermic patient. Look for key clues in the history such as medications taken, recent dose changes, and onset of symptoms. An easy way to remember the clinical features for the two syndromes are the mnemonics HARM and MAN. Once diagnosed, treatment revolves around discontinuation of the offending medications and supportive care. On further examination you also notice generalized “lead-pipe rigidity” in the patient. You make the diagnosis of neuroleptic malignant syndrome and ensure that no further doses of anti-psychotics are given; instead, you treat her with fluid resuscitation and continue to monitor her. You treat her agitation with benzodiazepines, but her symptoms persist and eventually admission to hospital is needed“