ALiEM - April 2, 2022 - By: Bryan D. Hayes and Mike O'Brien
Bottom Line
- The management of acute ischemic stroke in patients receiving prior anticoagulation presents a challenging clinical scenario.
- Studies to date fail to include enough patients to evaluate the true risk of bleeding.
- This study supports the current guideline recommendation to avoid alteplase in patients receiving a DOAC within 0-48 hours due to the increased risk of intracranial hemorrhage.
