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Saturday, September 17, 2022

Acetazolamide in ADHF

REBEL CRIT, REBEL EM - September 15, 2022 - By Salim Rezaie
Paper: Mullens W et al. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. NEJM 2022. PMID: 36027559 [Access on Read By QxMD
Clinical Question: Does the addition of acetazolamide to loop diuretics lead to more and faster decongestion in patients with acute decompensated heart failure with volume overload?
Author Conclusion: “The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulted in a greater incidence of successful decongestion.”
Clinical Take Home Point: In patients with acute decompensated heart failure, and clinical signs of volume overload (i.e. edema, pleural effusion, or ascites) the addition of 500mg of IV acetazolamide to standard loop diuretic therapy resulted in more diuresis, more natriuresis, shorter hospital stay, and an increased likelihood of being discharged without residual signs of volume overload.