emDOCs / EM@3AM - February 11, 2023 - By Jackie Nguyen; Joshua Kern
Reviewed by: Sophia Görgensmand and Cassandra Mackey; Alex Koyfman; Brit Long
Pearls
- Consider SJS/TEN when a patient is presenting with blistering rash and fever in the setting of new medication usage or recent viral illness.
- The rash will often have mucous membrane involvement and there can be extra-cutaneous manifestations.
- Medications to support suspicion include the following: NSAIDs, anticonvulsants, sulfa-derived, ß-lactams, antigout, contrast agents, and antiretrovirals.
- Cease medications suspected to be causative immediately and admit to a burn center if possible.